Methanol → Methyl 4-hydroxypiperidine-4-carboxylate

HRID 712212ノート

反応式

HRID 712212 の反応式
C([N:8]1[CH2:13][CH2:12][C:11]([OH:17])([C:14]([OH:16])=[O:15])[CH2:10][CH2:9]1)C1C=CC=CC=1.[CH3:18]O>[OH-].[Pd+2].[OH-]>[OH:17][C:11]1([C:14]([O:16][CH3:18])=[O:15])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

参加物

4

反応物 2

HCID 887MethanolHCID 203941814-Piperidinecarboxylicacid, 4-hydroxy-1-(phenylmethyl)-

生成物 1

HCID 21093366Methyl 4-hydroxypiperidine-4-carboxylate

試薬・触媒・溶媒 1

HCID 9942167Palladium hydroxide触媒

実験手順

To a stirred solution of 1-benzyl-4-hydroxypiperidine-4-carboxylic acid (1.2 g, 5.1 mmol) in MeOH (15 mL) was added palladium hydroxide and the resulting mixture was stirred at rt for 6 h under H2 atmosphere. After completion (by TLC), the mixture was passed through celite and the filtrate evaporated under reduced pressure. The crude (1 g) residue was carried forward to the next step without further purification. MS: 160.18 [M+H]+.

後処理

  1. customthe filtrate evaporated under reduced pressure
  2. customThe crude (1 g) residue was carried forward to the next step without further purification

出典と根拠

ORDレコード
ord-11ecec35c18a44528df52b212433cdca
出典データセット
uspto-grants-2015_11
特許番号
US09181234B2

反応ノート

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