2-Benzyl-hexahydro-cyclopenta[c]pyrrole-3a-carboxylic acid methyl ester → HCID 66977181、化合物

HRID 712225ノート

反応式

HRID 712225 の反応式
C([N:8]1[CH2:12][C:11]2([C:16]([O:18][CH3:19])=[O:17])[CH2:13][CH2:14][CH2:15][CH:10]2[CH2:9]1)C1C=CC=CC=1>CO.[OH-].[Pd+2].[OH-]>[CH2:9]1[CH:10]2[CH2:15][CH2:14][CH2:13][C:11]2([C:16]([O:18][CH3:19])=[O:17])[CH2:12][NH:8]1

参加物

4

反応物 1

HCID 41183282-Benzyl-hexahydro-cyclopenta[c]pyrrole-3a-carboxylic acid methyl ester

生成物 1

HCID 66977181HCID 66977181、化合物

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

To a stirred solution of methyl 2-benzyloctahydrocyclopenta[c]pyrrole-3a-carboxylate (2.0 g, 7.69 mmol) in MeOH (15.0 mL) was added palladium hydroxide (0.20 g, 10% w/w) and the mixture stirred at rt for 16 h under H2 atmosphere. After completion of reaction (by TLC), the reaction mixture was passed through celite and the solvent evaporated. The crude (1.50 g) residue was carried forward for the next step without further purification. MS: 170.18 [M+H]+.

後処理

  1. customAfter completion of reaction (by TLC)
  2. customthe solvent evaporated
  3. customThe crude (1.50 g) residue was carried forward for the next step without further purification

出典と根拠

ORDレコード
ord-09a6abba829b491280d5efffeeb37fb7
出典データセット
uspto-grants-2015_11
特許番号
US09181234B2

反応ノート

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