4-Piperidinecarboxylicacid, 4-hydroxy-1-(phenylmethyl)- → 4-hydroxypiperidine-4-carboxylic Acid
反応式
C([N:8]1[CH2:13][CH2:12][C:11]([OH:17])([C:14]([OH:16])=[O:15])[CH2:10][CH2:9]1)C1C=CC=CC=1>CCO.[OH-].[Pd+2].[OH-]>[OH:17][C:11]1([C:14]([OH:16])=[O:15])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1参加物
4
実験手順
To the solution of 1-benzyl-4-hydroxypiperidine-4-carboxylic acid (1.0 g, 4.25 mmol) in EtOH (15.0 mL) was added palladium hydroxide (0.40 g, 40% w/w) at rt and the mixture stirred at rt for 20 h under H2 atmosphere. After completion of reaction (by TLC) the mixture was passed through celite and the solvent evaporated. The crude (0.70 g) residue was carried forward for next step without further purification. MS: 145.99 [M+H]+.
後処理
- customAfter completion of reaction (by TLC) the mixture
- customthe solvent evaporated
- customThe crude (0.70 g) residue was carried forward for next step without further purification
出典と根拠
- ORDレコード
- ord-a7b19ad20be74b3bba2796b50d0ee09b
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09181234B2
反応ノート
読み込み中…