Thionyl Chloride → 4-Chloro-7-methoxyquinazolin-6-yl acetate

HRID 712375ノート

反応式

HRID 712375 の反応式
[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[O:15][CH3:16])[N:11]=[CH:10][NH:9][C:8]2=O)(=[O:3])[CH3:2].S(Cl)([Cl:20])=O>CN(C=O)C>[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[O:15][CH3:16])[N:11]=[CH:10][N:9]=[C:8]2[Cl:20])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 1356819606-Acetoxy-7-methoxy-3H-quinazolin-4-one

生成物 1

HCID 220221604-Chloro-7-methoxyquinazolin-6-yl acetate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
70 °C

実験手順

A suspension of 7-methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate (2.00 g), DMF (0.20 mL) and thionyl chloride (30 mL) was stirred at 70° C. for 3 h. The mixture was concentrated in vacuo, and the residue was used for the next step without further purification.

後処理

  1. concentrationThe mixture was concentrated in vacuo
  2. customthe residue was used for the next step without further purification

出典と根拠

ORDレコード
ord-a0cb960bfa2a472d98274a925c68df95
出典データセット
uspto-grants-2015_11
特許番号
US09181277B2

反応ノート

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