3-(Trifluoromethyl)-1,2,4-triazolo(4,3-a)pyrazine → 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-(1,2,4)triazolo(4,3-a)pyrazine
反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[N:7]2[CH:8]=[CH:9][N:10]=[CH:11][C:6]2=[N:5][N:4]=1>CO.[Pd]>[F:12][C:2]([F:1])([F:13])[C:3]1[N:7]2[CH2:8][CH2:9][NH:10][CH2:11][C:6]2=[N:5][N:4]=1参加物
4
実験手順
To a solution of 3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine (1.60 g) in methanol (20 mL) was added a catalytic amount of Pd/C. The suspension was stirred under H2 for 5 h, and then filtered. The filtrate was concentrated in vacuo to give a residue, which was used for next step without further purification.
後処理
- filtrationfiltered
- concentrationThe filtrate was concentrated in vacuo
- customto give a residue, which
- customwas used for next step without further purification
出典と根拠
- ORDレコード
- ord-8110480a3311460a8188d38255464ec7
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09181277B2
反応ノート
読み込み中…