Ethanol → tert-Butyl octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate
反応式
[N:1]1([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[C:5]2=[CH:6][N:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[CH:2]1.CCO>O=[Pt]=O.CC(O)=O>[N:1]1([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH:5]2[CH2:6][NH:7][CH2:8][CH2:9][CH:4]2[CH2:3][CH2:2]1参加物
5
実験手順
A mixture of tert-butyl 1H-pyrrolo[2,3-c]pyridine-1-carboxylate (1.85 g) and a catalytic amount of PtO2 in the mixture solvent of EtOH (10 mL) and AcOH (10 mL) was heated overnight under H2 (2.0 MPa). The reaction mixture was filtered, and the filtrate was concentrated in vacuo. The residue was chromatographed with a silica gel column (eluting agent: 10:1 (v/v) CH2Cl2/MeOH) to afford the product as viscous liquid (2.18 g, 100.00%).
後処理
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate was concentrated in vacuo
- customThe residue was chromatographed with a silica gel column (eluting agent: 10:1 (v/v) CH2Cl2/MeOH)
出典と根拠
- ORDレコード
- ord-9f3a1e671cc6476f842471b6ab1c6637
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09181277B2
反応ノート
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