Methanol → 1-Methyloctahydropyrrolo[3,4-b]pyridine
反応式
C([N:8]1[CH2:16][CH:15]2[CH:10]([N:11]([CH3:17])[CH2:12][CH2:13][CH2:14]2)[CH2:9]1)C1C=CC=CC=1.CO>[OH-].[OH-].[Pd+2].CCOC(C)=O>[CH3:17][N:11]1[CH2:12][CH2:13][CH2:14][CH:15]2[CH2:16][NH:8][CH2:9][CH:10]12参加物
5
実験手順
To a solution of 6-benzyl-1-methyloctahydro-1H-pyrrolo[3,4-b]pyridine (2.00 g) in the mixture solvent of MeOH and EtOAc was added a catalytic amount of 20% Pd(OH)2/C. The reaction mixture was stirred for 2 h at room temperature under H2. The resulted mixture was filtered and the filtrate was concentrated to in vacuo to give the crude product, which was used for the next step without further purification. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 141.2 (M+1).
後処理
- filtrationThe resulted mixture was filtered
- concentrationthe filtrate was concentrated to in vacuo
出典と根拠
- ORDレコード
- ord-ff4d879998284d0fac793ecf4944ea3c
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09181277B2
反応ノート
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