3,4-Dihydro-2H-pyrano[3,2-b]pyridine → HCID 68842904、化合物

HRID 712477ノート

反応式

HRID 712477 の反応式
[O:1]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1>COCCO.[Pd]>[O:1]1[CH:10]2[CH:5]([NH:6][CH2:7][CH2:8][CH2:9]2)[CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 1

HCID 124862493,4-Dihydro-2H-pyrano[3,2-b]pyridine

生成物 1

HCID 68842904HCID 68842904、化合物収率 90%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 80192-Methoxyethanol溶媒

反応条件

温度
70 °C

実験手順

To a solution of 3,4-dihydro-2H-pyrano[3,2-b]pyridine (0.60 g) in glycol monomethyl ether was added a catalytic amount of 10% Pd/C. The reaction mixture was stirred at 70° C. for 3 hours under H2 (2 MPa) and filtered. The filtrate was concentrated in vacuo to give the title compound as colorless oil (0.56 g, 90.00%), which was used for the next step without further purification. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 142.2 (M+1).

後処理

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-e0f1bc4483db4428b9c6b93ce7361e3c
出典データセット
uspto-grants-2015_11
特許番号
US09181277B2

反応ノート

読み込み中…