Triphenylphosphine → 3-Bromo-5-(bromomethyl)pyridine
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH2:8]O)[CH:5]=[N:6][CH:7]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1C(=O)N([Br:36])C(=O)C1>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[N:6][CH:5]=[C:4]([CH2:8][Br:36])[CH:3]=1参加物
5
実験手順
(5-Bromo-pyridin-3-yl)-methanol (500 mg, 2.7 mmol) and triphenylphosphine (840 mg, 3.2 mmol) are dissolved in 12 mL of DCM and NBS (570 mg, 3.2 mmol) is added. The mixture is stirred for 4 hrs and then the reaction mixture is directly purified by flash column chromatography give 455 mg of 3-bromo-5-bromomethyl-pyridine.
後処理
- customthe reaction mixture is directly purified by flash column chromatography
出典と根拠
- ORDレコード
- ord-f94edaf7e3f940ec97ec851b9df2b0a8
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09181272B2
反応ノート
読み込み中…