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HRID 712827作成日：2026年10月27日

1-((Tert-butoxy)carbonyl)-4,4-difluoropiperidine-2-carboxylic acid → Tert-butyl 4,4-difluoro-2-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)piperidine-1-carboxylate

https://huagongshe.com/reaction/712827

反応式

関与物質

役割名称HCID仕込み量
反応物1-((Tert-butoxy)carbonyl)-4,4-difluoropiperidine-2-carboxylic acidHCID 10106900—
反応物Methyl 4-(1-aminocyclopropyl)benzoate hydrochlorideHCID 66824369—
生成物Tert-butyl 4,4-difluoro-2-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)piperidine-1-carboxylateHCID 11796687469.4%

反応手順

The title compound (D68) (688 mg) was prepared according to the general procedure for amides preparation (Method C) starting from 1-(tert-butoxycarbonyl)-4,4-difluoropiperidine-2-carboxylic acid (600 mg; described in WO2010148197) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (566.5 mg). Reaction time: 5 hrs

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09181279B2
出典データセットuspto-grants-2015_11
ORD IDord-f42d9d81c8d142c3b6715110002965ae
出典メモuspto-grants-2015_11