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HRID712827

反应详情

EQUATION

反应方程式

HRID 712827 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)N1CCC(F)(F)CC1C(=O)O
HCID10106900

1-(TERT-BUTOXYCARBONYL)-4,4-DIFLUOROPIPERIDINE-2-CARBOXYLIC ACID

C11H17F2NO4

结构：COC(=O)c1ccc(C2(N)CC2)cc1.Cl
HCID66824369

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)c1ccc(C2(NC(=O)C3CC(F)(F)CCN3C(=O)OC(C)(C)C)CC2)cc1
HCID117966874

未命名化合物

收率 69.4%

PROCEDURE

实验过程

The title compound (D68) (688 mg) was prepared according to the general procedure for amides preparation (Method C) starting from 1-(tert-butoxycarbonyl)-4,4-difluoropiperidine-2-carboxylic acid (600 mg; described in WO2010148197) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (566.5 mg). Reaction time: 5 hrs

WORKUP

后处理

  1. customReaction time
  2. custom5 hrs