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Sodium Carbonate → 3-(Trifluoromethyl)benzyl 4-hydroxy-1-(3-(trifluoromethyl)benzyl)pyrrolidine-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 1-(Bromomethyl)-3-(trifluoromethyl)benzene | HCID 123061 | — |
| 反応物 | Cis-4-Hydroxy-D-Proline | HCID 440014 | — |
| 生成物 | 3-(Trifluoromethyl)benzyl 4-hydroxy-1-(3-(trifluoromethyl)benzyl)pyrrolidine-2-carboxylate | HCID 90353857 | — |
反応手順
The title compound (D81) (1.02 g) was prepared according to the general procedure for substituted benzyl amines preparation starting from cis-4-Hydroxy-D-proline (4.0 g; available from Aldrich#H5877) and 3-(Trifluoromethyl)benzyl bromide (9.37 ml). (Na2CO3: 2.5 eq; Reaction time: 24 hrs; 60° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09181279B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-47c1ce7c4c6d4ae78b39c83b454689b6 |
| 出典メモ | uspto-grants-2015_11 |