Sodium Carbonate → HCID 71186580、化合物

反応式

[CH3:1][C:2]1([C:10]([NH:12][C@H:13]([C:15]2[CH:24]=[CH:23][C:18]([C:19]([O:21][CH3:22])=[O:20])=[CH:17][CH:16]=2)[CH3:14])=[O:11])[NH:9][CH2:8][CH2:7][C:4]2([CH2:6][CH2:5]2)[CH2:3]1.[F:25][C:26]([F:36])([F:35])[C:27]1[CH:34]=[CH:33][C:30]([CH2:31]Br)=[CH:29][CH:28]=1.C([O-])([O-])=O.[Na+].[Na+]>>[CH3:1][C:2]1([C:10]([NH:12][C@H:13]([C:15]2[CH:16]=[CH:17][C:18]([C:19]([O:21][CH3:22])=[O:20])=[CH:23][CH:24]=2)[CH3:14])=[O:11])[N:9]([CH2:31][C:30]2[CH:29]=[CH:28][C:27]([C:26]([F:25])([F:35])[F:36])=[CH:34][CH:33]=2)[CH2:8][CH2:7][C:4]2([CH2:5][CH2:6]2)[CH2:3]1

参加物

反応物 3

HCID 10340Sodium Carbonate

HCID 1230621-(Bromomethyl)-4-(trifluoromethyl)benzene

HCID 71186341HCID 71186341、化合物

生成物 1

HCID 71186580HCID 71186580、化合物

実験手順

The title compound (D130) (19 mg) was prepared according to the general procedure for substituted benzyl amines preparation starting from methyl 4-((1S)-1-(5-methyl-6-azaspiro[2.5]octane-5-carboxamido)ethyl)benzoate (D92) (16 mg) and 4-(Trifluoromethyl)benzylbromide (0.011 ml). (Na2CO3: 3 eq; reaction time: 18 hrs; 68° C.)

出典と根拠

ORDレコード: ord-84bdb0e8d6cd4534b55e4cc7f668a7d2
出典データセット: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09181279B2

反応ノート

読み込み中…