4-Cyanophenylboronic acid → (rac)-4-(8-(3,4-Dimethylphenyl)-8-hydroxy-5,6,7,8-tetrahydroisoquinolin-4-yl)benzonitrile

HRID 714073

反応式

HRID 714073 の反応式
Br[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][C:7]([C:13]3[CH:18]=[CH:17][C:16]([CH3:19])=[C:15]([CH3:20])[CH:14]=3)([OH:12])[C:6]=2[CH:5]=[N:4][CH:3]=1.[C:21]([C:23]1[CH:28]=[CH:27][C:26](B(O)O)=[CH:25][CH:24]=1)#[N:22]>>[CH3:20][C:15]1[CH:14]=[C:13]([C:7]2([OH:12])[C:6]3[CH:5]=[N:4][CH:3]=[C:2]([C:26]4[CH:27]=[CH:28][C:23]([C:21]#[N:22])=[CH:24][CH:25]=4)[C:11]=3[CH2:10][CH2:9][CH2:8]2)[CH:18]=[CH:17][C:16]=1[CH3:19]

参加物

3

反応物 2

HCID 27343264-Cyanophenylboronic acidHCID 89846267(rac)-4-Bromo-8-(3,4-dimethylphenyl)-5,6,7,8-tetrahydroisoquinolin-8-ol

生成物 1

HCID 71811407(rac)-4-(8-(3,4-Dimethylphenyl)-8-hydroxy-5,6,7,8-tetrahydroisoquinolin-4-yl)benzonitrile収率 79%

実験手順

In analogy to the procedure described for the preparation of example 1, (rac)-4-bromo-8-(3,4-dimethylphenyl)-5,6,7,8-tetrahydroisoquinolin-8-ol (intermediate A-3) was reacted with 4-cyanophenylboronic acid to give the title compound as white powder in 79% yield. MS: 355.2 (M+H+).

出典と根拠

ORDレコード
ord-d5fc4687a2ee40b8b403260ee64fe309
出典データセット
uspto-grants-2015_11
特許番号
US09187429B2

関連ノート

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