(3-Methylpyridin-2-yl)methanol → 3-Methylpyridine-2-carboxaldehyde

HRID 7144

反応式

HRID 7144 の反応式
[OH:1][CH2:2][C:3]1[C:8]([CH3:9])=[CH:7][CH:6]=[CH:5][N:4]=1>C(Cl)Cl.O=[Mn]=O>[CH3:9][C:8]1[C:3]([CH:2]=[O:1])=[N:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 1514369(3-Methylpyridin-2-yl)methanol

生成物 1

HCID 15018743-Methylpyridine-2-carboxaldehyde収率 64%

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of 2-(hydroxymethyl)-3-methylpyridine (1.08 g, 8.77 mmol) in dry CH2Cl2 (45 mL) at room temperature was added MnO2 (8.09 g, 79.1 mmol). The mixture was stirred for 21 hrs then filtered through celite. The filtrate was concentrated to give 0.68 g (64%) of 3-methylpyridine-2-carboxaldehyde. 1H NMR (CDCl3) □ 2.66 (s, 3H), 7.39 (dd, 1H, J=8.3, 4.3 Hz), 7.63 (d, 1H, J=7.9 Hz), 8.66 (d, 1H, J=3.3 Hz), 10.19 (s, 1H). This was used without further purification.

後処理

  1. filtrationthen filtered through celite
  2. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-9b276c372b2c47e7b5b6464e07e242b6
出典データセット
uspto-grants-2006_08
特許番号
US07084155B2

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