(3-Methylpyridin-2-yl)methanol → 3-Methylpyridine-2-carboxaldehyde
反応式
[OH:1][CH2:2][C:3]1[C:8]([CH3:9])=[CH:7][CH:6]=[CH:5][N:4]=1>C(Cl)Cl.O=[Mn]=O>[CH3:9][C:8]1[C:3]([CH:2]=[O:1])=[N:4][CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
To a stirred solution of 2-(hydroxymethyl)-3-methylpyridine (1.08 g, 8.77 mmol) in dry CH2Cl2 (45 mL) at room temperature was added MnO2 (8.09 g, 79.1 mmol). The mixture was stirred for 21 hrs then filtered through celite. The filtrate was concentrated to give 0.68 g (64%) of 3-methylpyridine-2-carboxaldehyde. 1H NMR (CDCl3) □ 2.66 (s, 3H), 7.39 (dd, 1H, J=8.3, 4.3 Hz), 7.63 (d, 1H, J=7.9 Hz), 8.66 (d, 1H, J=3.3 Hz), 10.19 (s, 1H). This was used without further purification.
後処理
- filtrationthen filtered through celite
- concentrationThe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-9b276c372b2c47e7b5b6464e07e242b6
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07084155B2
反応ノート
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