N-(3-formylphenyl)methanesulfonamide → [3-(Hydroxyethyl)phenyl](methylsulfonyl)amine

HRID 714466

反応式

HRID 714466 の反応式
[CH:1]([C:3]1[CH:4]=[C:5]([NH:9][S:10]([CH3:13])(=[O:12])=[O:11])[CH:6]=[CH:7][CH:8]=1)=[O:2].[CH3:14][Mg]Br>O1CCCC1>[OH:2][CH:1]([C:3]1[CH:4]=[C:5]([NH:9][S:10]([CH3:13])(=[O:12])=[O:11])[CH:6]=[CH:7][CH:8]=1)[CH3:14]

参加物

4

反応物 2

HCID 2794787N-(3-formylphenyl)methanesulfonamideHCID 178418573HCID 178418573、化合物

生成物 1

HCID 43508614[3-(Hydroxyethyl)phenyl](methylsulfonyl)amine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Under argon and at 0° C., 83 mg (0.417 mmol) of N-(3-formylphenyl)methanesulfonamide (Example 86A) were initially charged in 1 ml of abs. tetrahydrofuran. At 0° C., 99 mg (0.833 mmol) of methylmagnesium bromide (3 M in diethyl ether) were added dropwise (resulting in the formulation of a precipitate), and the reaction solution was stirred at this temperature for 2 h. The reaction solution was quenched with water and extracted three times with ethyl acetate. The combined organic phases were dried over sodium sulfate, filtered and evaporated.

後処理

  1. customresulting in the formulation of a precipitate), and the reaction solution
  2. customThe reaction solution was quenched with water
  3. extractionextracted three times with ethyl acetate
  4. dry with materialThe combined organic phases were dried over sodium sulfate
  5. filtrationfiltered
  6. customevaporated

出典と根拠

ORDレコード
ord-9ebb46efaf6049d5b841395a69ffd1af
出典データセット
uspto-grants-2015_11
特許番号
US09187428B2

関連ノート

読み込み中…