Trifluoroacetic acid → HCID 17925871、化合物

HRID 714512ノート

反応式

HRID 714512 の反応式
C([O:5][C:6](=[O:19])[CH:7]=[C:8]1[CH2:13][CH2:12][CH:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:10][CH2:9]1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:17]([O:16][C:14]([CH:11]1[CH2:12][CH2:13][C:8](=[CH:7][C:6]([OH:19])=[O:5])[CH2:9][CH2:10]1)=[O:15])[CH3:18]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 18340695HCID 18340695、化合物

生成物 1

HCID 17925871HCID 17925871、化合物収率 134.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of ethyl 4-(2-tert-butoxy-2-oxoethylidene)cyclohexanecarboxylate (5.3 g, 21 mmol) in CH2Cl2 (30 ml) was added TFA (30 ml). The solution was stirred at room temperature overnight. The solution was concentrated in vacuo to afford 6 g of product as colorless oil, which was used directly for next step without further purification.

後処理

  1. concentrationThe solution was concentrated in vacuo

出典と根拠

ORDレコード
ord-bea00d74b052408f9587690813472c8b
出典データセット
uspto-grants-2015_11
特許番号
US09187447B2

反応ノート

読み込み中…