Hydrochloric Acid → 2-(4-(Methoxycarbonyl)-2-methylphenyl)acetic acid

HRID 714524ノート

反応式

HRID 714524 の反応式
C([O:3][C:4](=[O:17])[CH2:5][C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12][CH3:13])=[O:11])=[CH:8][C:7]=1[CH3:16])C.O.[Li+].[OH-].Cl>CO>[CH3:13][O:12][C:10]([C:9]1[CH:14]=[CH:15][C:6]([CH2:5][C:4]([OH:17])=[O:3])=[C:7]([CH3:16])[CH:8]=1)=[O:11]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 67365879Methyl 4-(2-ethoxy-2-oxoethyl)-3-methylbenzoate

生成物 1

HCID 575552242-(4-(Methoxycarbonyl)-2-methylphenyl)acetic acid収率 91.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl 4-(2-ethoxy-2-oxoethyl)-3-methylbenzoate (366 mg) was suspended in MeOH(10 ml) and H2O (2 ml) and treated with LiOH (48 mg) over 3 days. After the reaction mixture was acidified with 1N HCl, the product was extracted with EtOAc. Evaporation and drying in vacuum afforded the desired product (295 mg).

後処理

  1. extractionthe product was extracted with EtOAc
  2. customEvaporation
  3. customdrying in vacuum

出典と根拠

ORDレコード
ord-13c55a5b75694ab0bd94317153354e56
出典データセット
uspto-grants-2015_11
特許番号
US09187447B2

反応ノート

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