Water → N-(5-Nitro-pyrimidin-2-yl)-benzamide

HRID 714576

反応式

HRID 714576 の反応式
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[C:11](Cl)(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.O>N1C=CC=CC=1>[C:11]([NH:1][C:2]1[N:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1)(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

5

反応物 3

HCID 962WaterHCID 7412Benzoyl chlorideHCID 764905-Nitropyrimidin-2-amine

生成物 1

HCID 57699955N-(5-Nitro-pyrimidin-2-yl)-benzamide収率 45.3%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To stirred solution of 2-amino-5-nitropyrimidine (1.0 g, 7.14 mmol) in pyridine (20 ml) was added benzoyl chloride (0.92 ml, 7.93 mmol). The mixture was refluxed for 4 hr under nitrogen atmosphere. The reactant mixture was cooled to the room temperature and poured into 200 ml water. The resulting mixture was stirred overnight and then filtered in vacuo. The filter cake was washed with water (20 ml*3) and dried in vacuo to give 2-(N-benzoyl)amino-5-nitropyrimidine as a white solid (790 mg).

後処理

  1. temperatureThe mixture was refluxed for 4 hr under nitrogen atmosphere
  2. filtrationfiltered in vacuo
  3. washThe filter cake was washed with water (20 ml*3)
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-4703bc90db2a4c779ad15f3d7b8b4ead
出典データセット
uspto-grants-2015_11
特許番号
US09187458B2

関連ノート

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