6-Aminoindole → 5-fluoro-N4-(3-hydroxyphenyl)-N2-[(1H)-indol-6-yl]-2,4-pyrimidinediamine

HRID 71464

反応式

HRID 71464 の反応式
C1COC2C=CC(NC3C(F)=CN=C(NC4C=CC=C(O)C=4)N=3)=CC=2O1.Cl[C:28]1[N:33]=[C:32]([NH:34][C:35]2[CH:40]=[CH:39][CH:38]=[C:37]([OH:41])[CH:36]=2)[C:31]([F:42])=[CH:30][N:29]=1.[NH2:43][C:44]1[CH:52]=[C:51]2[C:47]([CH:48]=[CH:49][NH:50]2)=[CH:46][CH:45]=1>>[F:42][C:31]1[C:32]([NH:34][C:35]2[CH:40]=[CH:39][CH:38]=[C:37]([OH:41])[CH:36]=2)=[N:33][C:28]([NH:43][C:44]2[CH:52]=[C:51]3[C:47]([CH:48]=[CH:49][NH:50]3)=[CH:46][CH:45]=2)=[N:29][CH:30]=1

参加物

4

反応物 3

HCID 2560966-AminoindoleHCID 22060334N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-primidinediamineHCID 220604512-chloro-5-fluoro-N-(3-hydroxyphenyl)-4-pyrimidineamine

生成物 1

HCID 220602765-fluoro-N4-(3-hydroxyphenyl)-N2-[(1H)-indol-6-yl]-2,4-pyrimidinediamine

実験手順

In a manner similar to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidinediamine, 2-chloro-5-fluoro-N4-(3-hydroxyphenyl)-4-pyrimidineamine and 6-aminoindole were reacted to yield 5-fluoro-N4-(3-hydroxyphenyl)-N2-[(1H)-indol-6-yl]-2,4-pyrimidinediamine. LCMS: ret. time: 18.13 min.; purity: 96%; MS (m/e): 336 (MH+).

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-24aa8f6cc6f1497fbeacb72ca1677944
出典データセット
uspto-grants-2014_09
特許番号
US08822685B2

関連ノート

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