4-Fluorobenzoyl chloride → N-(3-Cyano-4,5-dihydro-2-furanyl)-4-fluorobenzamide
反応式
[NH2:1][C:2]1[O:3][CH2:4][CH2:5][C:6]=1[C:7]#[N:8].[F:9][C:10]1[CH:18]=[CH:17][C:13]([C:14](Cl)=[O:15])=[CH:12][CH:11]=1>N1C=CC=CC=1>[C:7]([C:6]1[CH2:5][CH2:4][O:3][C:2]=1[NH:1][C:14](=[O:15])[C:13]1[CH:17]=[CH:18][C:10]([F:9])=[CH:11][CH:12]=1)#[N:8]参加物
4
実験手順
To a solution of 2-amino-4,5-dihydrofuran-3-carbonitrile (3.5 g) obtained in Step D in pyridine (8 mL) was added dropwise 4-fluorobenzoyl chloride (5.5 g) in an ice bath, and the mixture was stirred at room temperature for 3 hr. The solvent was evaporated under reduced pressure, and to the residue was added dropwise saturated aqueous sodium hydrogen carbonate solution in an ice bath. The resulting solid was collected by filtration, and washed with water to give the title compound (7.1 g).