2,6-Difluorobenzoic acid → Sodium 2,6-difluorobenzoate

HRID 714930ノート

反応式

HRID 714930 の反応式
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([OH:6])=[O:5].[OH-].[Na+:13]>CCO.O>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([O-:6])=[O:5].[Na+:13]

参加物

5

反応物 2

HCID 97962,6-Difluorobenzoic acidHCID 14798Sodium Hydroxide

生成物 1

HCID 23698872Sodium 2,6-difluorobenzoate収率 100%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

To a solution of 2,6-difluorobenzoic acid (1.00 g, 6.3 mmol) in EtOH and water (5:1, 60 mL) was added 1N aqueous sodium hydroxide solution (6.33 mL, 6.3 mmol). The reaction mixture was stirred for 10 minutes at room temperature and then solvents were removed in vacuo to yield sodium 2,6-difluorobenzoate (1.22 g, 6.3 mmol, quantitative) as an off white solid. 1H NMR (DMSO) δ 6.89 (2H, m), 7.15 (1H, m).

後処理

  1. customsolvents were removed in vacuo

出典と根拠

ORDレコード
ord-42caf2d19a924c09b8ec9a72668f2496
出典データセット
uspto-grants-2015_11
特許番号
US09187465B2

反応ノート

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