Thionyl Chloride → 2-(Chloromethyl)-6-(2,2,2-trifluoroethoxy)pyridine
反応式
[F:1][C:2]([F:14])([F:13])[CH2:3][O:4][C:5]1[N:10]=[C:9]([CH2:11]O)[CH:8]=[CH:7][CH:6]=1.S(Cl)([Cl:17])=O>C(Cl)Cl>[Cl:17][CH2:11][C:9]1[CH:8]=[CH:7][CH:6]=[C:5]([O:4][CH2:3][C:2]([F:14])([F:13])[F:1])[N:10]=1参加物
4
実験手順
A mixture of (6-(2,2,2-trifluoroethoxy)pyridin-2-yl)methanol (0.32 g, 1.55 mmol, Step-3), and thionyl chloride (0.23 mL, 3.10 mmol) in DCM (16 mL) is stirred at rt for 1 hour. The organic solvent is concentrated under reduced pressure and dried to give 0.35 g (>99% yield) of the title compound as yellow oil. This material is used for the next reaction (Step-5) without further purification.
後処理
- concentrationThe organic solvent is concentrated under reduced pressure
- customdried
出典と根拠
- ORDレコード
- ord-42240215459f465aab73064358618287
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09187475B2
反応ノート
読み込み中…