Thionyl Chloride → Ethyl 5-chloro-6-(chloromethyl)nicotinate hydrochloride
反応式
[Cl:1][C:2]1[C:3]([CH2:13]O)=[N:4][CH:5]=[C:6]([CH:12]=1)[C:7]([O:9][CH2:10][CH3:11])=[O:8].S(Cl)([Cl:17])=O>C(Cl)Cl>[ClH:1].[Cl:1][C:2]1[C:3]([CH2:13][Cl:17])=[N:4][CH:5]=[C:6]([CH:12]=1)[C:7]([O:9][CH2:10][CH3:11])=[O:8]参加物
4
実験手順
To a solution of ethyl 5-chloro-6-(hydroxymethyl)nicotinate (990 mg, 4.59 mmol, Step-2) in DCM (20 mL) is added thionyl chloride (0.80 mL, 9.2 mmol) at 0° C. After stirring at rt for 2 hours, the solvent is removed in vacuo to give 1.20 g (97% yield) of the title compound as brown oil.
後処理
- customthe solvent is removed in vacuo
出典と根拠
- ORDレコード
- ord-05701a66edbc459bba2e38445538cce1
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09187475B2
反応ノート
読み込み中…