Sodium Bicarbonate → 1-(4-Bromophenyl)piperidin-4-ol

HRID 715560ノート

反応式

HRID 715560 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][C:11](=[O:14])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[BH4-].[Na+].C([O-])(O)=O.[Na+]>CO>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:9][CH2:10][CH:11]([OH:14])[CH2:12][CH2:13]2)=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 516892Sodium BicarbonateHCID 4311764Sodium borohydrideHCID 246921481-(4-Bromophenyl)piperidin-4-one

生成物 1

HCID 235052161-(4-Bromophenyl)piperidin-4-ol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
0 °C

実験手順

1-(4-Bromophenyl)piperidin-4-one (765 mg) is dissolved under argon in MeOH (8 mL), cooled to 0° C. and treated with NaBH4 (145 mg). The mixture is stirred for 2 hours at 0° C., treated with saturated aqueous NaHCO3 solution and stirred for 10 minutes. Then the mixture is extracted with ethylacetate and the organic phase is washed with brine and dried (MgSO4). The solvents are evaporated to give the title compound. LC (method 2): tR=0.92 min; Mass spectrum (ESI+): m/z=256 [M+H]+.

後処理

  1. stirringstirred for 10 minutes
  2. extractionThen the mixture is extracted with ethylacetate
  3. washthe organic phase is washed with brine
  4. dry with materialdried (MgSO4)
  5. customThe solvents are evaporated

出典と根拠

ORDレコード
ord-3d95ece6ff234f99847e4c9a3d22fdb0
出典データセット
uspto-grants-2015_11
特許番号
US09187477B2

反応ノート

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