Sodium Hydroxide → HCID 86701047、化合物
反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]2[N:13]=[C:14]([S:17][CH:18]([CH2:24][CH3:25])[C:19]([O:21]CC)=[O:20])[CH:15]=[CH:16][C:11]2=[N:10][N:9]=1.[OH-].[Na+]>O1CCOCC1>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]2[N:13]=[C:14]([S:17][CH:18]([CH2:24][CH3:25])[C:19]([OH:21])=[O:20])[CH:15]=[CH:16][C:11]2=[N:10][N:9]=1参加物
4
実験手順
To a solution of ethyl 2-((3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)butanoate (1 mmol) in dioxane (3 mL) was added 0.5 ml of sodium hydroxide (2N), and the reaction mixture was stirred at room temperature. After 2 hours, the mixture was evaporated to dryness, and the obtained residue dissolved in water (2 mL) and then acidified with an hydrochloric acid solution. The resulting precipitate was filtered, washed with water, and dried to give 2-((3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)butanoic acid.