Triethyl(methoxycarbonylsulfamoyl)aminium → 2-Neopentyl-5-(4-nitrophenyl)-1,3,4-oxadiazole

HRID 715829ノート

反応式

HRID 715829 の反応式
[CH3:1][C:2]([CH3:20])([CH3:19])[CH2:3][C:4]([NH:6][NH:7][C:8](=[O:18])[C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=1)=O.C([N+](CC)(CC)S(NC(=O)OC)(=O)=O)C>O1CCCC1>[CH2:3]([C:4]1[O:18][C:8]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)=[N:7][N:6]=1)[C:2]([CH3:20])([CH3:19])[CH3:1]

参加物

4

反応物 2

HCID 2724995Triethyl(methoxycarbonylsulfamoyl)aminiumHCID 4628581N'-(3,3-dimethylbutanoyl)-4-nitrobenzohydrazide

生成物 1

HCID 867020152-Neopentyl-5-(4-nitrophenyl)-1,3,4-oxadiazole

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
120 °C

実験手順

A mixture of N′-(3,3-dimethylbutanoyl)-4-nitrobenzohydrazide (0.556 g, 1.991 mmol) and methyl N-(triethylammoniumsulfonyl)carbamate (0.572 g, 2.389 mmol) in tetrahydrofuran (10 ml) was heated to 120° C. in a microwave (Biotage Initiator) for 45 minutes. The crude reaction mixture was concentrated and purified by normal phase chromatography to give the title compound.

後処理

  1. customThe crude reaction mixture
  2. concentrationwas concentrated
  3. custompurified by normal phase chromatography

出典と根拠

ORDレコード
ord-33d919d6e8434710aa3900b1dfceb2de
出典データセット
uspto-grants-2015_11
特許番号
US09187472B2

反応ノート

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