Carbon Tetrachloride → 2-Bromo-5-bromomethylpyridine

HRID 71668

反応式

HRID 71668 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][N:3]=1.C(Cl)(Cl)(Cl)Cl.C1C(=O)N([Br:21])C(=O)C1>C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][Br:21])=[CH:4][N:3]=1

参加物

5

反応物 3

HCID 5943Carbon TetrachlorideHCID 67184N-bromobutanimideHCID 5642162-Bromo-5-methylpyridine

生成物 1

HCID 64246602-Bromo-5-bromomethylpyridine収率 105.4%

試薬・触媒・溶媒 1

HCID 7187Benzoyl Peroxide触媒

反応条件

温度
0 °C

実験手順

To a solution of 2-Bromo-5-methylpyridine (3.1 g, 17.4 mmol) in carbon tetrachloride (40 mL, 400 mmol) was added benzoyl peroxide (230 mg, 950 μmol) and NBS (3.4 g, 19.2 mmol). The resulting mixture was heated at reflux overnight. The mixture was cooled at 0° C. and the NBS was removed by filtration. The filtrate was concentrated to yield 2-bromo-5-bromomethylpyridine (4.6 g), which was used directly in the next step.

後処理

  1. temperatureThe resulting mixture was heated
  2. temperatureat reflux overnight
  3. customthe NBS was removed by filtration
  4. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-cef9ca7e4a984936b559bd23095e3b06
出典データセット
uspto-grants-2014_09
特許番号
US08822522B2

関連ノート

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