Sodium Hydroxide → 3-Chlorophenylglyoxylic acid

HRID 716732ノート

反応式

HRID 716732 の反応式
[OH-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([C:10](=[O:16])[C:11]([O:13]CC)=[O:12])[CH:7]=[CH:8][CH:9]=1>C1COCC1.CO>[Cl:3][C:4]1[CH:5]=[C:6]([C:10](=[O:16])[C:11]([OH:13])=[O:12])[CH:7]=[CH:8][CH:9]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 2758814ethyl 2-(3-chlorophenyl)-2-oxoacetate

生成物 1

HCID 122529103-Chlorophenylglyoxylic acid収率 115.2%

試薬・触媒・溶媒 1

HCID 21899815MeOH tetrahydrofuran溶媒

実験手順

An aqueous 2 mol/L NaOH solution (24 mL) was added to a solution of ethyl (3-chlorophenyl)(oxo)acetate (2.00 g) in THF/MeOH (1:1) (48 mL) in an ice bath, followed by stirring at room temperature overnight. The solvent was distilled off under reduced pressure, and an aqueous 3 mol/L HCl solution was added thereto in an ice bath. The precipitated solid was collected by filtration to yield the title compound (2.00 g, colorless solid).

後処理

  1. distillationThe solvent was distilled off under reduced pressure
  2. additionan aqueous 3 mol/L HCl solution was added
  3. filtrationThe precipitated solid was collected by filtration

出典と根拠

ORDレコード
ord-ed40ffaa3da34e729845a2fd9b3e881b
出典データセット
uspto-grants-2015_11
特許番号
US09193695B2

反応ノート

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