Sodium Hydroxide → 4,5-Difluoropyridin-2-amine

N-(4,5-difluoropyridin-2-yl)-2,2-dimethylpropanamide (47-2; 0.380 g) in concentrated HCl was heated at 95° C. for 5 h. The reaction mixture was cooled to RT, diluted with ice cold water (20 mL) and basified with 10% aqueous sodium hydroxide solution. The reaction mixture was extracted with ethyl acetate (2×50 mL). The combined organic layers were dried over sodium sulphate and concentrated under vacuum to afford the title compound. 1H NMR (400 MHz, DMSO) δ 7.72-7.67 (m, 1H), 6.59-6.55 (m, 1H), 6.48 (bs, 2H).

1. extractionThe reaction mixture was extracted with ethyl acetate (2×50 mL)
2. dry with materialThe combined organic layers were dried over sodium sulphate
3. concentrationconcentrated under vacuum

ORDレコード

ord-b4b3293e37d641bda96414702ddc8cef

出典データセット

uspto-grants-2015_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09193724B2