Hydrogen Peroxide → HCID 58515933、化合物

HRID 717831ノート

反応式

HRID 717831 の反応式
[Cl:1][C:2]1[N:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].FC(F)(F)C(O)=[O:16].OO>>[Cl:1][C:2]1[N+:11]([O-:16])=[CH:10][C:9]([Cl:12])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]

参加物

4

反応物 3

HCID 784Hydrogen PeroxideHCID 6422Trifluoroacetic acidHCID 2764318Methyl 2,5-Dichloronicotinate

生成物 1

HCID 58515933HCID 58515933、化合物収率 99%

反応条件

温度
70 °C

実験手順

A solution of methyl 2,5-dichloronicotinate (15 g, 73 mmol), trifluoroacetic acid (91 mL) and 30% aqueous hydrogen peroxide solution (15 mL) were stirred and heated at 70° C. for 1 hour. Evaporation and purification by flash column chromatography using ethyl acetate in hexanes (0-100%) gave the desired product (16 g, 99%). LCMS calculated for C7H6Cl2NO3 (M+H)+: m/z=222.0. found: 221.8.

後処理

  1. customEvaporation and purification by flash column chromatography

出典と根拠

ORDレコード
ord-eb3fe48cfd20478b97e96c017f9c91e4
出典データセット
uspto-grants-2015_11
特許番号
US09193721B2

反応ノート

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