Triethyl(methoxycarbonylsulfamoyl)aminium → 2-Neopentyl-5-(4-nitrophenyl)-1,3,4-oxadiazole

HRID 717987ノート

反応式

HRID 717987 の反応式
[CH3:1][C:2]([CH3:20])([CH3:19])[CH2:3][C:4]([NH:6][NH:7][C:8](=[O:18])[C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=1)=O.C([N+](CC)(CC)S(NC(=O)OC)(=O)=O)C>O1CCCC1>[CH2:3]([C:4]1[O:18][C:8]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)=[N:7][N:6]=1)[C:2]([CH3:20])([CH3:19])[CH3:1]

参加物

4

反応物 2

HCID 2724995Triethyl(methoxycarbonylsulfamoyl)aminiumHCID 4628581N'-(3,3-dimethylbutanoyl)-4-nitrobenzohydrazide

生成物 1

HCID 867020152-Neopentyl-5-(4-nitrophenyl)-1,3,4-oxadiazole

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
120 °C

実験手順

A mixture of N′-(3,3-dimethylbutanoyl)-4-nitrobenzohydrazide (0.556 g, 1.991 mmol) and methyl N-(triethylammoniumsulfonyl)carbamate (0.572 g, 2.389 mmol) in tetrahydrofuran (10 ml) was heated to 120° C. in a microwave for 45 minutes. The crude reaction mixture was concentrated and purified by normal phase chromatography to give the title compound.

後処理

  1. customThe crude reaction mixture
  2. concentrationwas concentrated
  3. custompurified by normal phase chromatography

出典と根拠

ORDレコード
ord-3c6bd70555a84d25aa4f010817244a7d
出典データセット
uspto-grants-2015_11
特許番号
US09193723B2

反応ノート

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