反応式
[CH3:1][C:2]1([CH3:18])[O:6][B:5]([C:7]2[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][CH:8]=2)[O:4][C:3]1([CH3:17])[CH3:16].[NH2:19][C@@H:20]([CH:28]([CH3:30])[CH3:29])[C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C>CN(C=O)C>[CH3:29][CH:28]([CH3:30])[C@H:20]([NH:19][C:11](=[O:13])[C:10]1[CH:9]=[CH:8][C:7]([B:5]2[O:4][C:3]([CH3:17])([CH3:16])[C:2]([CH3:1])([CH3:18])[O:6]2)=[CH:15][CH:14]=1)[C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22]参加物
6
反応物 4
生成物 1
試薬・触媒・溶媒 1
実験手順
To a solution of 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid (2.0 g, 8.1 mmol) and (S)-tert-butyl 2-amino-3-methylbutanoate (2.0 g, 9.5 mmol) in DMF (10 mL) were added HATU (6.1 g, 16 mmol) and DIEA (4.2 g, 33 mmol). The reaction mixture was stirred at rt overnight. The reaction was then quenched with water (100 mL). The resulting mixture was extracted with DCM (2×100 mL), and the organic layer was concentrated under reduced pressure. The residue obtained was purified by flash column chromatography on silica gel (EtOAc/petroleum ether (1:50)) to obtain compound 43a as a white solid. Mass Spectrum (LCMS, ESI pos.): Calcd. for C22H34BNO5: 404.3 (M+H). Found 404.1.
後処理
- customThe reaction was then quenched with water (100 mL)
- extractionThe resulting mixture was extracted with DCM (2×100 mL)
- concentrationthe organic layer was concentrated under reduced pressure
- customThe residue obtained
- customwas purified by flash column chromatography on silica gel (EtOAc/petroleum ether (1:50))
出典と根拠
- ORDレコード
- ord-14d3c46333c44293a5b6c184d775eb9e
- 出典データセット
- uspto-grants-2015_11
- 特許番号
- US09193736B2
関連ノート
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