N-bromobutanimide → 6-(Bromomethyl)phenanthridine

HRID 718738ノート

反応式

HRID 718738 の反応式
[Br:1]N1C(=O)CCC1=O.[CH3:9][C:10]1[N:11]=[C:12]2[C:17](=[C:18]3[C:23]=1[CH:22]=[CH:21][CH:20]=[CH:19]3)[CH:16]=[CH:15][CH:14]=[CH:13]2>C1C=CC=CC=1>[Br:1][CH2:9][C:10]1[N:11]=[C:12]2[C:17](=[C:18]3[C:23]=1[CH:22]=[CH:21][CH:20]=[CH:19]3)[CH:16]=[CH:15][CH:14]=[CH:13]2

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 3179886-Methylphenanthridine

生成物 1

HCID 856742386-(Bromomethyl)phenanthridine収率 87.1%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

N-bromosuccinimide (557 mg, 3.13 mmol) was added to a solution of the phenanthridine 5 (403 mg, 2.09 mmol) in benzene (20 mL) and the reaction mixture was stirred while lit with a tungsten lamp (150 W) for 45 minutes. The reaction crude, including precipitated succinimide, was deposited onto silica and purified by flash chromatography eluting with CH2Cl2. Evaporation of the solvent under reduced pressure yielded the bromo 6 as a white solid (495 mg, 87.1%).

後処理

  1. customThe reaction crude
  2. customincluding precipitated succinimide
  3. custompurified by flash chromatography
  4. washeluting with CH2Cl2
  5. customEvaporation of the solvent under reduced pressure

出典と根拠

ORDレコード
ord-4db0c1c2e10e4417a053660a0e858854
出典データセット
uspto-grants-2015_11
特許番号
US09194802B2

反応ノート

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