1,4-Dibromobutane → HCID 21896329、化合物

HRID 719064ノート

反応式

HRID 719064 の反応式
[Mg].Br[CH2:3][CH2:4][CH2:5][CH2:6]Br.[O:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[C:13]([O:15]CC)=O.[Cl-].[NH4+]>O1CCCC1>[O:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[C:13]1([OH:15])[CH2:6][CH2:5][CH2:4][CH2:3]1

参加物

6

反応物 4

HCID 80561,4-DibromobutaneHCID 25517Ammonium ChlorideHCID 5462224MagnesiumHCID 101032862-Furancarboxylic acid, tetrahydro-, ethyl ester

生成物 1

HCID 21896329HCID 21896329、化合物収率 89.9%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
60 °C

実験手順

A flask was charged with 13.6 g of magnesium and 300 ml of tetrahydrofuran, to which 60.3 g of 1,4-dibromobutane was added dropwise at 50° C. After the completion of dropwise addition, the solution was stirred at 60° C. for one hour. To the solution below 40° C., 31.0 g of ethyl tetrahydrofurancarboxylate was added dropwise. The solution was stirred at room temperature for one hour, after which an aqueous solution of ammonium chloride was added for hydrolysis. Ordinary post-treatment yielded 30.2 g of 1-(2-tetrahydrofuranyl)cyclopentanol.

後処理

  1. additionwas added dropwise at 50° C
  2. additionAfter the completion of dropwise addition
  3. stirringThe solution was stirred at room temperature for one hour

出典と根拠

ORDレコード
ord-11ceea0086bb4303ad4a745dd0285ed8
出典データセット
uspto-grants-2006_11
特許番号
US07132215B2

反応ノート

読み込み中…