Bromine → HCID 178524228、化合物
反応式
[OH:1][C:2]1[C:7]2=[CH:8][CH:9]=[C:10]3[C:19]([N:18]=[C:17]4[C:12]([CH:13]=[CH:14][CH:15]=[C:16]4[C:20]([OH:22])=[O:21])=[N:11]3)=[C:6]2[CH:5]=[CH:4][CH:3]=1.[Br:23]Br>C(Cl)(Cl)Cl>[Br:23][C:3]1[CH:4]=[CH:5][C:6]2=[C:19]3[C:10](=[CH:9][CH:8]=[C:7]2[C:2]=1[OH:1])[N:11]=[C:12]1[C:17]([C:16]([C:20]([OH:22])=[O:21])=[CH:15][CH:14]=[CH:13]1)=[N:18]3参加物
4
実験手順
A mixture of 4-hydroxy-benzo[a]phenazine-11-carboxylic acid (see Reference Example 1K, 102 mg) and bromine (0.04 mL) was stirred in chloroform (3 mL) at room temperature for 20 hours. The solvent was removed in vacuo and the residue was purified using flash chromatography (10% methanol in dichloromethane) to yield the title compound (24 mg) as a yellow-brown solid.
後処理
- customThe solvent was removed in vacuo
- customthe residue was purified