Triethylamine → N-((Methoxycarbonyl)methyl)4-Nitrophenylalanine Methyl Ester

HRID 719663ノート

反応式

HRID 719663 の反応式
C(N(CC)CC)C.Cl.[CH3:9][O:10][C:11](=[O:24])[C@H:12]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1)[NH2:13].[CH3:25][O:26][C:27](=[O:30])[CH2:28]Br>C1COCC1>[CH3:9][O:10][C:11](=[O:24])[C@H:12]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1)[NH:13][CH2:28][C:27]([O:26][CH3:25])=[O:30]

参加物

5

反応物 3

HCID 8471Triethylamine2 回HCID 60984Methyl bromoacetateHCID 11715866Methyl 4-nitro-L-phenylalaninate hydrochloride

生成物 1

HCID 68574020N-((Methoxycarbonyl)methyl)4-Nitrophenylalanine Methyl Ester収率 92%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Triethylamine (22 mmol) was added to a suspension of 4-Nitrophenylalanine methyl ester hydrochloride (2) (21 mmol) in THF (50 ml). The mixture was stirred at room temperature for one hour, the triethylamine hydrochloride was filtered off, and the filtrate concentrated to yellow oil. The oil was dissolved in dry THF (50 ml) and to this solution was added triethylamine (60 mmol) and methylbromoacetate (60 mmol), the solution was stirred at room temperature under nitrogen atmosphere for 3 hours, after which the precipitate was filtered off and the filtrate concentrated on vacuum. The residue was dissolved in ethylacetate, washed with H2O, dried (MgSO4) and concentrated on vacuum to give yellow oil. The yield was 92%.

後処理

  1. filtrationthe triethylamine hydrochloride was filtered off
  2. concentrationthe filtrate concentrated to yellow oil
  3. dissolutionThe oil was dissolved in dry THF (50 ml) and to this solution
  4. stirringthe solution was stirred at room temperature under nitrogen atmosphere for 3 hours
  5. filtrationafter which the precipitate was filtered off
  6. concentrationthe filtrate concentrated on vacuum
  7. dissolutionThe residue was dissolved in ethylacetate
  8. washwashed with H2O
  9. dry with materialdried (MgSO4)
  10. concentrationconcentrated on vacuum
  11. customto give yellow oil

出典と根拠

ORDレコード
ord-1d361a77553743f0b595134964d1542c
出典データセット
uspto-grants-2006_11
特許番号
US07132513B2

反応ノート

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