Methanol → Penicillamine methyl ester

HRID 719667

反応式

HRID 719667 の反応式
[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[C:3]([SH:6])([CH3:5])[CH3:4].S(Cl)(Cl)=O.[CH3:14]O>>[NH2:1][C@@H:2]([C:3]([SH:6])([CH3:5])[CH3:4])[C:7]([O:9][CH3:14])=[O:8]

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 92863L-Penicillamine

生成物 1

HCID 153004Penicillamine methyl ester収率 100%

実験手順

To a methanol (18 mL, 1.14 M) solution containing L-penicillamine (3.0 g, 20.11 mmol, 1.0 eq) was added thionyl chloride (1.5 mL, 20.7 mmol, 1.03 eq). The resulting mixture was heated to reflux for 18 hr and the solvent removed in vacuo. The resulting clear semi-solid was used in the next step without further purification. Isolated 3.28 g (20.1 mmol, 100% yield).

後処理

  1. temperatureThe resulting mixture was heated
  2. temperatureto reflux for 18 hr
  3. customthe solvent removed in vacuo
  4. customThe resulting clear semi-solid was used in the next step without further purification
  5. customIsolated 3.28 g (20.1 mmol, 100% yield)

出典と根拠

ORDレコード
ord-bd5e1b8e45af41ca92ca3e05f5afe5be
出典データセット
uspto-grants-2006_11
特許番号
US07132443B2

関連ノート

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