HCID 59611073、化合物 → (S)-benzyl 2-amino-4-(difluoromethoxy)butanoate
反応式
C(OC([NH:8][C@@H:9]([CH2:20][CH2:21][O:22][CH:23]([F:25])[F:24])[C:10]([O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:11])=O)(C)(C)C>C(O)(C(F)(F)F)=O.ClCCl>[NH2:8][C@@H:9]([CH2:20][CH2:21][O:22][CH:23]([F:24])[F:25])[C:10]([O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:11]参加物
4
実験手順
(S)-benzyl 2-(tert-butoxycarbonylamino)-4-(difluoromethoxy)butanoate (161 mg, 0.448 mmol) was stirred in 30% TFA in dichloromethane (5 mL) for 1 h. The resulting mixture was concentrated down on rotovap and redissolved and concentrated down with toluene three times, and finally the residue was dried on high vacuum pump. The desired product was used as-is in the next step.
後処理
- concentrationThe resulting mixture was concentrated down on rotovap
- dissolutionredissolved
- concentrationconcentrated down with toluene three times
- customfinally the residue was dried on high vacuum pump
出典と根拠
- ORDレコード
- ord-9116f2349cf74ab28a4f5baec091cfaf
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08822430B2
反応ノート
読み込み中…