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1-(4-Nitrophenyl)pyrrolid-3-yl methanesulphonate → [3-(Imidazol-1-yl)propyl][1-(4-nitrophenyl)pyrrolid-3-yl]amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(4-Nitrophenyl)pyrrolid-3-yl methanesulphonate | HCID 12067814 | — |
| 反応物 | 3-(1H-Imidazol-2-yl)propan-1-amine | HCID 13290797 | — |
| 生成物 | [3-(Imidazol-1-yl)propyl][1-(4-nitrophenyl)pyrrolid-3-yl]amine | HCID 58737022 | 48.2% |
反応手順
30 g (0.105 mol) of 1-(4-nitrophenyl)pyrrolid-3-yl methylsulphonate (2) were heated at 90° C. for 18 hours with 120 g of aminopropylimidazole (0.958 mol). This mixture was poured into ice-cold water and the product was extracted with dichloromethane. The yellow powder obtained was chromatographed, eluting with dichloromethane/methanol (98/2), and 15.2 g of derivative (7) were recovered (48.2% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07132534B2 |
| 出典データセット | uspto-grants-2006_11 |
| ORD ID | ord-a22814a64c224890ada0c015d65c5f49 |
| 出典メモ | uspto-grants-2006_11 |