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Azobisisobutyronitrile → 2'-Bromomethyl-biphenyl-3-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Azobisisobutyronitrile | HCID 6547 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | Ethyl 2'-methyl[1,1'-biphenyl]-3-carboxylate | HCID 12853045 | — |
| 反応物 | 4'-Bromomethyl-biphenyl-3-carboxylic acid ethyl ester | HCID 21464255 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | 2'-Bromomethyl-biphenyl-3-carboxylic acid ethyl ester | HCID 58610590 | — |
反応手順
2′-Bromomethyl-biphenyl-3-carboxylic acid ethyl ester was synthesized as described for 4′-bromomethyl-biphenyl-3-carboxylic acid ethyl ester. 2′-Methyl-biphenyl-3-carboxylic acid ethyl ester (8.3 g, 34.54 mmol, 1 eq.) in carbon tetrachloride was treated with N-bromosuccinimide (7.38 g, 41.45 mmol, 1.2 eq.) and 2,2′-azobisisobutyronitrile (0.28 g, 1.73 mmol, 5 mol %). When complete, the reaction was worked up as described leaving an orange oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07132456B2 |
| 出典データセット | uspto-grants-2006_11 |
| ORD ID | ord-93a2a49a9d544b53b0a780eed22a98f2 |
| 出典メモ | uspto-grants-2006_11 |