反应详情

2′-Bromomethyl-biphenyl-3-carboxylic acid ethyl ester was synthesized as described for 4′-bromomethyl-biphenyl-3-carboxylic acid ethyl ester. 2′-Methyl-biphenyl-3-carboxylic acid ethyl ester (8.3 g, 34.54 mmol, 1 eq.) in carbon tetrachloride was treated with N-bromosuccinimide (7.38 g, 41.45 mmol, 1.2 eq.) and 2,2′-azobisisobutyronitrile (0.28 g, 1.73 mmol, 5 mol %). When complete, the reaction was worked up as described leaving an orange oil.

1. customas described leaving an orange oil