Tetrahydrofuran → N-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)-3-(1-pyrrolyl)phenyl)-2-chloro-5-nitrobenzamide

HRID 719763

反応式

HRID 719763 の反応式
O1CCCC1.[Cl:6][C:7]1[C:8]([O:17][C:18]2[CH:24]=[CH:23][C:21]([NH2:22])=[CH:20][C:19]=2[N:25]2[CH:29]=[CH:28][CH:27]=[CH:26]2)=[N:9][CH:10]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:12]=1.C(N(CC)CC)C.[Cl:37][C:38]1[CH:46]=[CH:45][C:44]([N+:47]([O-:49])=[O:48])=[CH:43][C:39]=1[C:40](Cl)=[O:41]>O>[Cl:6][C:7]1[C:8]([O:17][C:18]2[CH:24]=[CH:23][C:21]([NH:22][C:40](=[O:41])[C:39]3[CH:43]=[C:44]([N+:47]([O-:49])=[O:48])[CH:45]=[CH:46][C:38]=3[Cl:37])=[CH:20][C:19]=2[N:25]2[CH:29]=[CH:28][CH:27]=[CH:26]2)=[N:9][CH:10]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:12]=1

参加物

6

反応物 4

HCID 8028Tetrahydrofuran2 回HCID 8471TriethylamineHCID 117637Benzoyl chloride, 2-chloro-5-nitro-HCID 219018824-(3-Chloro-5-trifluoromethyl-2-pyridyloxy)-3-(1-pyrrolyl)aniline

生成物 1

HCID 10280324N-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)-3-(1-pyrrolyl)phenyl)-2-chloro-5-nitrobenzamide収率 53.5%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To 5 mL of a tetrahydrofuran solution comprising 320 mg of 4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)-3-(1-pyrrolyl)aniline and 110 mg of triethylamine, 5 mL of a tetrahydrofuran solution comprising 200 mg of 2-chloro-5-nitrobenzoylchloride was dropwise added, followed by stirring for about 30 minutes, and then water was added, and the precipitated crystals were collected by filtration. The collected crystals were washed with water and then dried to obtain 260 mg of N-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)-3-(1-pyrrolyl)phenyl)-2-chloro-5-nitrobenzamide (Compound No. 127) having a melting point of from 165 to 167° C.

後処理

  1. additionwas dropwise added
  2. filtrationthe precipitated crystals were collected by filtration
  3. washThe collected crystals were washed with water
  4. customdried

出典と根拠

ORDレコード
ord-871385b06bda4191b3074811150b6d83
出典データセット
uspto-grants-2006_11
特許番号
US07132546B2

関連ノート

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