Thionyl Chloride → 2-(4-Chlorophenyl)-2-methylpropanoyl chloride

HRID 720035ノート

反応式

HRID 720035 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:13])([CH3:12])[C:9](O)=[O:10])=[CH:4][CH:3]=1.S(Cl)([Cl:16])=O>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:13])([CH3:12])[C:9]([Cl:16])=[O:10])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 24386Thionyl Chloride2 回HCID 804062-(4-Chlorophenyl)-2-methylpropionic acid

生成物 1

HCID 135368632-(4-Chlorophenyl)-2-methylpropanoyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
40 °C

実験手順

2-(4-chlorophenyl)-2-methyl propionyl chloride was prepared as follows: To a flask containing 2-(4-chlorophenyl)-2-methyl propionic acid (15.0 g, 75.6 mmol) was added thionyl chloride (approx. 6 mL). Dichloromethane (20 mL) was then added before adding an additional portion of thionyl chloride (approx. 12 mL). The reaction was allowed to heat to 40° C. for two hours before cooling to room temperature and concentrating in vacuo (azeotroping with tetrahydrofuran). The resulting acid chloride was used in the following acylation step without further purification or characterization.

後処理

  1. temperaturebefore cooling to room temperature
  2. concentrationconcentrating in vacuo (azeotroping with tetrahydrofuran)
  3. customThe resulting acid chloride was used in the following acylation step without further purification or characterization

出典と根拠

ORDレコード
ord-ed833fa7d99b4c339465990fbf30bbf0
出典データセット
uspto-grants-2006_11
特許番号
US07132551B2

反応ノート

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