Trifluoroacetic acid → HCID 21901708、化合物
反応式
C(OC([N:8]1[CH2:12][CH:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:10][CH:9]1[CH2:21][CH:22]=[CH2:23])=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:21]([CH:9]1[CH2:10][CH:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:12][NH:8]1)[CH:22]=[CH2:23]参加物
4
実験手順
2-Allyl-4-benzyloxy-pyrrolidine-1-carboxylic acid tert-butyl ester, 51, (0.76 g, 2.4 mmol) is dissolved in methylene chloride (33 mL), and trifluoroacetic acid (25 mL) is added. The reaction mixture is stirred for 1 hour and then concentrated in vacuo. MeOH (40 mL) is added and the solvent is removed in vacuo to afford the desired product in approximately quanitative yield as a viscous oil which is used without further purification.
後処理
- concentrationconcentrated in vacuo
- additionMeOH (40 mL) is added
- customthe solvent is removed in vacuo
出典と根拠
- ORDレコード
- ord-afea64692fb74b62a91960ed6973c908
- 出典データセット
- uspto-grants-2006_11
- 特許番号
- US07132539B2
反応ノート
読み込み中…