Water → HCID 21889067、化合物

HRID 720209ノート

反応式

HRID 720209 の反応式
F[C:2]1[CH:3]=[C:4]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[NH2:11][CH2:12][CH2:13][CH2:14][N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1.O>CS(C)=O>[N:15]1([CH2:14][CH2:13][CH2:12][NH:11][C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-:10])=[O:9])[CH:3]=2)[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1

参加物

5

反応物 3

HCID 962WaterHCID 98231-Fluoro-3-nitrobenzeneHCID 61055N-(3-Aminopropyl)morpholine

生成物 1

HCID 21889067HCID 21889067、化合物

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
100 °C

実験手順

28.2 g 3-fluoronitrobenzene and 158.4 g 4-(3-aminopropyl)morpholine were dissolved in 300 ml dimethyl sulfoxide, and the batch was stirred for 60 h at 100° C. After cooling, the batch was poured into 1 l water. The mixture was extracted several times with methyl tert-butyl ether, and the combined organic phases were reduced to dryness on a rotary evaporator. The product obtained was an orange-brown oil.

後処理

  1. temperatureAfter cooling
  2. extractionThe mixture was extracted several times with methyl tert-butyl ether
  3. customthe combined organic phases were reduced to dryness on a rotary evaporator
  4. customThe product obtained

出典と根拠

ORDレコード
ord-27f356cf96fd4822bd7368b1137ae8c1
出典データセット
uspto-grants-2006_11
特許番号
US07135047B2

反応ノート

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