Hydrazine hydrate (1:1) → 1-(2,3-Difluorobenzyl)hydrazine

HRID 720251ノート

反応式

HRID 720251 の反応式
O.[NH2:2][NH2:3].[F:4][C:5]1[C:12]([F:13])=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7]Br>>[F:4][C:5]1[C:12]([F:13])=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7][NH:2][NH2:3]

参加物

3

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 5179841-(Bromomethyl)-2,3-difluoro-benzene

生成物 1

HCID 218916681-(2,3-Difluorobenzyl)hydrazine

実験手順

Preparation takes place in analogy to that described in Example 1 A from 2.74 g (54.75 mmol) of hydrazine hydrate and 3.02 g (14.60 mmol) of 2,3-difluorobenzyl bromide. For work up, the residue is purified by flash chromatography (mobile phase: dichloromethane:methanol 30:1–10:1).

後処理

  1. customPreparation
  2. customFor work up, the residue is purified by flash chromatography (mobile phase: dichloromethane:methanol 30:1–10:1)

出典と根拠

ORDレコード
ord-ca5266b8025c473c8b407e460e678a9f
出典データセット
uspto-grants-2006_11
特許番号
US07135474B2

反応ノート

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