Quinoline → HCID 10424702、化合物

HRID 720408ノート

反応式

HRID 720408 の反応式
[NH+:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[N:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13][CH:12]=1.[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=O.C(=O)(O)[O-:31].[Na+].[C:35](#[N:38])C=C>CN(C)C=O>[C:35]([C:16]1[CH:17]=[C:18]([C:19]([C:20]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)=[O:31])[N:1]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH:4]=[CH:3][C:2]=12)#[N:38]

参加物

7

反応物 5

HCID 7047QuinolineHCID 7855AcrylonitrileHCID 24503Dichromate ionHCID 516892Sodium BicarbonateHCID 4992033Quinolinium

生成物 1

HCID 10424702HCID 10424702、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
93 °C

実験手順

A stirred solution of 2-acetylpyridine (450 μL, 4.02 mmol), quinoline (5.0 mL, 42 mmol) and iodine (1.02 g, 4.01 mmol) was refluxed at 105° C. for 2 h under argon. The solution was cooled to room temperature and was concentrated by rotary evaporation in a water bath at 75° C. The residue was dissolved in ethanol (4 mL) and precipitated out by the addition of ethyl acetate (20 mL). The precipitate was filtered and dried in vacuo to yield 384 mg of a brownish-green solid as mixture of the product quinolinium salt and quinoline starting material. The solid (353 mg) was mixed with tetrapyridinecobalt(II) dichromate (591 mg, 0.970 mmol), sodium bicarbonate (199 mg, 2.37 mmol), acrylonitrile (310 μL, 4.71 mmol), and N,N-dimethylformamide (3.0 mL) and was refluxed at 93° C. for 2.5 h. The solution was cooled to room temperature and was concentrated by rotary evaporation. The product was purified by flash column chromatography (7:2 hexanes/ethyl acetate) and was recrystallized from ethyl acetate and dichloromethane to yield 31.6 mg (3% over 2 steps) of the title compound as a yellow solid. 1H NMR (CDCl3): 8.80 (dd, J=4.94, 0.82 Hz, 1H), 8.23 (d, J=7.96 Hz, 1H), 8.12 (d, J=8.24 Hz, 1H), 7.98 (td, J=7.76, 1.56 Hz, 1H), 7.85 (m, 2H), 7.76 (d, J=9.06 Hz, 1H), 7.68 (d, J=9.07 Hz, 1H), 7.52–7.65 (m, 3H).

後処理

  1. temperatureThe solution was cooled to room temperature
  2. concentrationwas concentrated by rotary evaporation
  3. customThe product was purified by flash column chromatography (7:2 hexanes/ethyl acetate)
  4. customwas recrystallized from ethyl acetate and dichloromethane

出典と根拠

ORDレコード
ord-3cefa754c9aa46309a399275923ec744
出典データセット
uspto-grants-2006_11
特許番号
US07135480B2

反応ノート

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