HCID 14969713、化合物 → HCID 14969720、化合物

HRID 720608ノート

反応式

HRID 720608 の反応式
[NH2:1][C:2]1[NH:7][C:6](=[O:8])[N:5]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:4](=[O:16])[C:3]=1[N:17]=O.[H][H]>C(O)C.O=[Pt]=O>[CH2:9]([N:5]1[C:4](=[O:16])[C:3]([NH2:17])=[C:2]([NH2:1])[NH:7][C:6]1=[O:8])[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

参加物

5

反応物 2

HCID 14969713HCID 14969713、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 14969720HCID 14969720、化合物

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒

実験手順

This compound can also be prepared by a method similar to that of Wells et al. as described in J. Med. Chem. 1981, 24(8), 954. Catalytic reduction of 6-amino-3-benzyl-5-nitroso-1H-pyrimidine-2,4-dione using PtO2 in ethanol at 50 psi of hydrogen at room temperature. Once the reduction is complete the catalyst is filtered off through a pad of Celite and the filtrate concentrated to give 3-benzyl-5,6-diamino-1H-pyrimidine-2,4-dione as a tan solid.

後処理

  1. customThis compound can also be prepared by a method similar to that of Wells et al.
  2. customat room temperature
  3. filtrationis filtered off through a pad of Celite
  4. concentrationthe filtrate concentrated

出典と根拠

ORDレコード
ord-4196ca5c4e614db2931d3e618a88d288
出典データセット
uspto-grants-2006_11
特許番号
US07135475B2

反応ノート

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