Uracil → HCID 178474113、化合物

HRID 720656

反応式

HRID 720656 の反応式
FC(F)(F)C([NH:5]C1C=CC(CC(O)=O)=CC=1)=O.[C:18]([NH:21][C:22]1[CH:27]=[CH:26][C:25](CC(O)=O)=[CH:24][CH:23]=1)(=[O:20])[CH3:19].N1C=CC(=O)NC1=O>>[N:5].[C:18]([NH:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)(=[O:20])[CH3:19]

参加物

4

反応物 3

HCID 1174Uracil2 回HCID 2018ActaritHCID 825287{4-[(Trifluoroacetyl)amino]phenyl}acetic acid

生成物 1

HCID 178474113HCID 178474113、化合物

実験手順

This compound was prepared by a method similar to that described in example 11 (method 1) except that [4-(2,2,2-trifluoro-acetylamino)-phenyl]-acetic acid (prepared by the method of K. D. Janda et al, as described in J. Amer. Chem. Soc. 1991, 113, 291) was used in place of (4-acetylamino-phenyl)-acetic acid. A mixture of products arising from mono-alkylation at the 1 position of the 1H-pyrimidine-2,4-dione and bis-alkylation at both the 1 position of the 1H-pyrimidine-2,4-dione and acetanilide nitrogen were obtained. When this mixture of compounds was directly subjected to the conditions used to effect cyclization to the xanthine the trifluoroacetyl groups were removed by hydrolysis. A 2:1 mixture of 8-(amino-benzyl)-3-butyl-1-(2-fluorobenzyl)-3,7-dihydro-purine-2,6-dione and 3-butyl-8-(4-butylamino-benzyl)-1-(2-fluorobenzyl)-3,7-dihydro-purine-2,6-dione was obtained which was separated by chromatography using silica gel eluted with 96:4 chloroform/methanol. MS, m/z(M+)=421.1914.

後処理

  1. customThis compound was prepared by a method similar to
  2. customprepared by the method of K
  3. additionA mixture of products

出典と根拠

ORDレコード
ord-092549754f244f38977d3dbefa233536
出典データセット
uspto-grants-2006_11
特許番号
US07135475B2

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